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. 2022 Feb 11;149(3):dev200250. doi: 10.1242/dev.200250

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Dynamics of the H3K27ac mark following NeuroD1 expression. (A) Schematic of analysing H3K27ac dynamics upon NeuroD1 expression. (B) Global dynamics of H3K27ac enrichment before and after NeuroD1 induction (12 h and 48 h). R1 and R2 are replicates. (C) Boxplots show average H3K27ac enrichment in each cluster (C1 to C7). Middle bars show median values, boxes show first to third interquartile ranges, whiskers show the minimum and maximum of data range and beyond that are outliers. (D) NeuroD1-bound and transcriptionally induced sites. (E) Motif enrichment profiles at transcriptionally active and inactive sites.