Fig. 6.

A schematic showing how the functional cooperativity of Tcf12 and NeuroD1 in specific subpopulations of the developing cortex creates the gene regulatory program essential for neuronal migration. Both Tcf12 and NeuroD1 are highly co-expressed during the transition of cortical progenitors from proliferative to neurogenic divisions. During this phase, Tcf12 forms a complex with NeuroD1 and co-occupies a subset of NeuroD1 target loci. This Tcf12-NeuroD1 cooperativity is essential for a gain in active chromatin and expression of neuronal migration genes, and therefore for the correct migration of newborn neurons.