Fig. 4.

Meis2 is required for the development of olfactory bulb interneurons. (A,B) Compared with controls, the number of BCL11B-positive cells was reduced in Meis2-CKO mice at P0 in the striatum. (C,D) More SP8-positive cells were observed in the LGE SVZ of Meis2-CKO mice (arrows). (E-H) The cell number of the SP8- and CB-positive cells was increased in the GCL and decreased in the GL. (I,J) There was a significant reduction in TH-positive cells in the GL of the Meis2-CKO mice at P0. (K,L) The expression of PAX6 was significantly reduced in the GL. (M,N) Quantification of above experiments. *P<0.05, **P<0.01, ***P<0.001 (one-way ANOVA followed by Tukey–Kramer post-hoc test). n=4 mice per group, mean±s.e.m. Dotted lines mark the border of the olfactory bulb core. GCL, granule cell layer; GL, glomerular layer. Scale bar: 200 µm in L for A-L.