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. 2022 Feb 23;149(4):dev200035. doi: 10.1242/dev.200035

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© 2022. Published by The Company of Biologists Ltd

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Fig. 8. — A model of the mechanism by which Meis2 regulates striatal MSN development. (A,B) Proliferating and immature cells accumulated in the lateral ganglionic eminence SVZ in Meis2-CKO mice, compared with control mice. Notably, the Meis2-CKO mice have an enlarged SVZ and a small striatum. (C) The main transcription factor network regulating the fate determination of striatal MSNs. First, Dlx1/2 promote the expression of Meis2 by enhancers such as hs599 and hs355. Then, Meis2 promotes Zfp503 or Six3 expression to further determine precursor cell fate (D1 or D2 MSNs). Cx, cortex; LV, lateral ventricle; MSN, medium-sized spiny neurons; MZ, mantle zone; Str, striatum; SVZ, subventricular zone; VZ, ventricular zone.