FIGURE 4.
Two faces of the NaV1.5–AahII molecular interaction presentation. The two faces of the NaV1.5–AahII molecular interaction are presented with an orientation of 180°. The subunit involved in the interaction was colored in red and AahII scorpion toxin in green. The extracellular S3–S4 loop part of the subunit interacting with AahII is presented in spheres. This molecular orientation is selected among hundreds of poses according to a very accurate molecular docking approach. The zoomed part illustrated in a circle shows the most crucial residues involved in the complex interaction and maintaining a stable molecular orientation. These residues make H-bounds, as well as hydrophobic and hydrophilic interactions.