TABLE 2.
Mean serum concentrations (micrograms per milliliter) in five uninfected mice after a single dose of antimicrobial agent
| Antimicrobial agenta | 30 min | 60 min | 90 min |
|---|---|---|---|
| Amoxicillin (25 mg/kg p.o.) | 12.0 | 3.8 | 1.3 |
| Azithromycin (100 mg/kg p.o.) | 0.8 | 1.2 | 1.8 |
| Ciprofloxacin (100 mg/kg p.o.) | 5.4 | 2.5 | 1.5 |
| Clarithromycin (100 mg/kg p.o.) | 3.2 | 3.9 | 2.8 |
| Erythromycin A (100 mg/kg i.p.) | 6.1 | 4.2 | 3.6 |
| HMR 3004 (50 mg/kg p.o.) | 3.2 | 4.8 | 4.5 |
| HMR 3647 (50 mg/kg p.o.) | 3.2 | 4.3 | 3.9 |
| Pristinamycin (100 mg/kg p.o.) | 2.2 | 0.8 | 0.8 |
a
p.o., orally; i.p., intraperitoneally.