TABLE 3.
Results of treatment of murine H. influenzae experimental pneumoniaa
| Treatment | No. sterile/total no. of animals | Median log10 CFU/g of lung | Range (25th–75th percentile) |
|---|---|---|---|
| None | 0/35 | 9.05 | 8.65–9.57 |
| Amoxicillin | 0/15 | 8.56 | 7.28–9.70 |
| Azithromycin | 5/18 | 3.93 | 1.70–4.23 |
| Ciprofloxacin | 3/13 | 3.33 | 2.06–3.94 |
| Clarithromycin | 0/12 | 5.73 | 5.57–6.00 |
| Erythromycin A | 0/12 | 5.40 | 5.07–5.69 |
| HMR 3004 | 9/14 | 1.70 | 1.70–3.75 |
| HMR 3647 | 3/12 | 4.34 | 2.08–5.08 |
| Pristinamycin | 0/14 | 7.35 | 6.50–8.37 |
a
There were two deaths among the ciprofloxacin- and clarithromycin-treated animals, one death among the HMR 3004- and pristinamycin-treated animals, and three deaths among the erythromycin- and HMR 3647-treated animals. Accidental gall bladder puncture occurred in one clarithromycin-treated animal at the time of sacrifice. These animals are not represented in the analysis shown.