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. Author manuscript; available in PMC: 2022 Mar 14.
Published in final edited form as: Eur J Med Chem. 2021 Dec 2;228:114011. doi: 10.1016/j.ejmech.2021.114011

Table 1.

IC50 (nM) values for HDACs inhibition with TMP195 in a panel of cancer cells using class-distinguishing fluorogenic substrates whole-cell assay.

 
 Cell type
THP-1 Panc-1 L3.6 HT-29
Class IIa HDACs 887 888 ± 230 893 ± 225 1004 ± 216
Class I/IIb HDACs >5000 >5000 >5000 >5000