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. Author manuscript; available in PMC: 2022 Mar 14.
Published in final edited form as: Eur J Med Chem. 2021 Dec 2;228:114011. doi: 10.1016/j.ejmech.2021.114011

Table 3.

IC50 values for HDACs inhibition in HT-29 cells using class-distinguishing fluorogenic substrates whole-cell assay..

graphic file with name nihms-1774621-t0012.jpg
# R X Class-Ila (uM) Class-I/IIb (uM)
9 graphic file with name nihms-1774621-t0013.jpg CH >5 >15
10 graphic file with name nihms-1774621-t0014.jpg CH 0.933 ± 0.26 >15
11 graphic file with name nihms-1774621-t0015.jpg CH 0.768 ± 0.19 >15
12 graphic file with name nihms-1774621-t0016.jpg CH 0.905 ± 0.31 >15
13 graphic file with name nihms-1774621-t0017.jpg CH 0.953 ± 0.31 >15
14 graphic file with name nihms-1774621-t0018.jpg CH 0.537 ± 0.15 >15
15 graphic file with name nihms-1774621-t0019.jpg N 1.710 ± 0.33 >15
16 graphic file with name nihms-1774621-t0020.jpg CH 0.233±0.11 >15
17 graphic file with name nihms-1774621-t0021.jpg CH 0.395 ± 0.14 >50
18 graphic file with name nihms-1774621-t0022.jpg N 0.147 ± 0.07 >50
19 graphic file with name nihms-1774621-t0023.jpg CH 0.059 ± 0.016 >15
1 (NT160) graphic file with name nihms-1774621-t0024.jpg CH 0.046 ±0.015 >15