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Development of Solid-Phase, Metal-Free Photochemical Hydroalkylation Conditions
| |||
|---|---|---|---|
| entry | deviation from initial conditions | 3b (conva) | 3b (% yielda) |
| 1 | none | 100 | 90 |
| 2 | under argon | 100 | 88 |
| 3 | under argon with DIPEA | 100 | 90 |
| 4 | Rink amide polystyrene resin | 100 | 90 |
| 5 | no Hantzsch ester | 0 | 0 |
| 6 | no light | 0 | 0 |
| 7 | >5 equiv HE and RAE | no improvement | no improvement |
| 8 | <5 equiv HE and RAE | inconsistent conv | inconsistent yield |
Product yield and conversion determined by crude NMR.
