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. 2022 Feb 28;16:846584. doi: 10.3389/fnins.2022.846584

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Copyright © 2022 Zhao, Lv, Yang and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of rapamycin on the behavioral changes of mice in open field at 5 days after tail vein injection of MMS. (A) Trajectories and density maps of mice in four groups: Normal + PBS, Normal + Rapa, MMS + PBS, MMS + Rapa. (B) The histogram of the total distance of the mice. Two way ANOVA was analyzed, ****P < 0.0001 for difference between MMS + PBS and Normal + PBS, ^####P < 0.0001 for difference between MMS + Rapa and MMS + PBS, n = 6. (C) The histogram of the percentage of center duration of mice. Two way ANOVA was analyzed, ****P < 0.0001 for difference between MMS + PBS and Normal + PBS, ^##P < 0.01 for difference between MMS + Rapa and MMS + PBS, n = 6/group.