. 1999 Mar;43(3):714–716. doi: 10.1128/aac.43.3.714

TABLE 2.

In vitro release of pefloxacin by the three lactic acid polymers

Day(s)	Pefloxacin levels (μg/ml) (mean ± SD) achieved by polymer with molecular mass of:
Day(s)	2 kDa^a ^b	26 kDa^a ^c	100 kDa^a ^d
1	40	395^*	2,164^**
2	96.2^‡	203^**	1,872^§^**
3–7	152.4 ± 31.6^‡	37 ± 14.1^**	1,307.6 ± 168^†^**
8–12	470.3 ± 149.7^†	33 ± 9.1^§^*	778.6 ± 67.6^†^*^§
13–20	642.9 ± 178.3^§	158.8 ± 35.3^**	553.5 ± 43.8^**^§
21–30	209.1 ± 71.5^*	244 ± 25.9^*^§	371.7 ± 52.8^***
31–35	107.8 ± 12.3^†	376 ± 53.7^**	307 ± 18.9^‡‡^*
36–40	82.1 ± 9.2^†	815 ± 232.9^†^*	327 ± 72.6^§^†^*
41–47	50.2 ± 9.9^*	1,191 ± 255.7^‡^*	263.4 ± 41.9^§^**
48–56	29.6 ± 3.6^*	793.4 ± 81^**	284.6 ± 50.8^§^**
57–73		610.3 ± 139^‡	398.6 ± 86^‡‡
74–82		403.3 ± 50.2^‡	312 ± 0.37^§§
83–102		260.1 ± 36.7^*	279 ± 27.8^§§
103–144			255.6 ± 25.6^§
145–210			154.6 ± 24.3^*
211–295			54.7 ± 24.4^*
Total amount (mg) of released pefloxacin	12.05	45.29	70.94

Statistical differences are indicated as follows: ∗, P < 0.001; †, P < 0.01; ‡, P < 0.05; §, not significant.

Symbols refer to comparisons with the corresponding values for release on the previous day(s).

Except for the value for day 1, for which the symbol refers to comparison with the corresponding value for the 2-kDa polymer, the first symbol refers to comparison with the corresponding value for the previous day; the second symbol, if given, refers to comparison with the corresponding value for the 2-kDa polymer.

Except for the value for day 1, for which the first and second symbols refer to comparisons with the 2- and 26-kDa polymers, respectively, the first symbol refers to comparison with release on the previous day(s), the second symbol, if given, refers to comparison with the corresponding value for the 26-kDa polymer, and the third symbol, if given, refers to comparison with the corresponding value for the 2-kDa polymer.