Figure 1.

Model of chronic thromboembolic pulmonary hypertension in rats caused by repeated intravenous administration of partially biodegradable sodium alginate microspheres. A. Representative microphotographs of the branches of the pulmonary artery by histological examination at different periods of observation after embolization, staining: hematoxylin–eosin, scale bar: 50 μm, green arrows indicate microspheres in the lumen of the vessels. B. Scheme of experiment. C. Dynamics of changes in right ventricular systolic pressure (RVSP) at different times after embolization. ∗p < 0.05 in comparison with the control group. D. Assessment of exercise tolerance according to the treadmill test. ∗p < 0.05 in comparison with the control group, #p < 0.05 in comparison with the 0-week subgroup, and p < 0.05 in comparison with the 18-week subgroup. E. The diameter of the main pulmonary artery (MPA). ∗p < 0.05 in comparison with the control group. #p < 0.05 in comparison with the 0-week subgroup.