Table 3.
Analysis of the correlation of known CRBN-associated partners and regulators with dBET1 DC50
| Gene | Category | Correlation coefficient | P. value |
|---|---|---|---|
| CRBN | CRBN and partner | −0.494871713 | 0.00543 |
| FBXO7 | CRBN and partner | −0.419334578 | 0.02107 |
| UBE2D3 | CRBN and partner | −0.32612564 | 0.07861 |
| ARIH1 | E3 Ligase Regulator | −0.312511312 | 0.09269 |
| DDB1 | CRBN and partner | −0.302250886 | 0.10451 |
| COPS5 | E3 Ligase Regulator | −0.291339995 | 0.11828 |
| UBE2H | E3 Ligase Regulator | 0.255081944 | 0.1737 |
| CUL4A | CRBN and partner | −0.199830715 | 0.28972 |
| UBE2G1 | CRBN and partner | −0.098374884 | 0.60503 |
| DCUN1D1 | E3 Ligase Regulator | −0.077538506 | 0.68381 |
| CUL4B | CRBN and partner | −0.018342434 | 0.92336 |
| NAE1 | E3 Ligase Regulator | −0.006346605 | 0.97345 |
| RBX1 | E3 Ligase Regulator | −0.001237036 | 0.99482 |
Correlation analysis results of known CRBN E3 machinery partners and E3 ligases regulators with dBET1 DC50 were shown as correlation coefficient and p value of the correlation test. A negative correlation coefficient represents a positive association with dBET1 activity and vice versa.