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. Author manuscript; available in PMC: 2022 Mar 14.
Published in final edited form as: Cell Rep. 2022 Feb 15;38(7):110388. doi: 10.1016/j.celrep.2022.110388

Figure 1. POWV-LB and POWV-Spooner cause morbidity and mortality in C57BL/6 mice.

Figure 1.

(A) Mortality of C57BL/6 (B6) mice challenged subcutaneously (s.c.) with 103(n = 6) or 102(n = 12) focus-forming units (FFU) of POWV-LB and monitored for 14 days post infection (dpi).

(B) Weight loss for B6 mice challenged s.c. with POWV-LB and monitored for 14 dpi.

(C) Clinical scoring results for B6 mice challenged s.c. with 103 FFU (middle, n = 5), and 102 FFU (right, n=8) of POWV-LB and monitored for 16 dpi.

(D) Mortality of B6 mice challenged s.c. with 103 (n = 12) or 102(n = 12) FFU of POWV-Spo and monitored for 30 dpi.

(E) Weight loss for B6 mice challenged s.c. with POWV-Spo and monitored for weight loss for 16 dpi.

(F) Clinical scoring results for mice B6 mice challenged s.c. with 103 FFU(left, n = 9) or 102 FFU(right, n = 10) of POWV-Spo and monitored for 16 dpi. Prior exposure to 102 FFU of POWV-Spooner significantly (p = 0.0002, Mantel-Cox test) improved POWV-LB survival. All data are reported as mean±SEM.