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. Author manuscript; available in PMC: 2022 Mar 14.
Published in final edited form as: Cell Rep. 2022 Feb 15;38(7):110388. doi: 10.1016/j.celrep.2022.110388

Figure 5. POWV-LB neuroinvasive disease and death occurs independent of host immune response.

Figure 5.

(A and B) Mortality (A) and weight loss (B) of NOD SCID gamma (NSG) (n = 5), recombination-activating gene 1-deficient (Rag1−/−, n = 5), and C57BL/6 (B6, n = 6) mice challenged s.c. with 102 FFU POWV-LB and monitored for 14 dpi. Immunocompromised mice survived significantly longer than B6 counterparts (pNSG = 0.0443, pRag1−/− = 0.0493, Mantel-Cox test). There was no difference between NSG and Rag1−/−mice (p = 0.65, Mantel-Coxtest).

(C and D) Mortality (C) and weight loss (D) for saline Rag1−/− (n = 8) mice, as well as recipient Rag1−/− mice that received POWV-Spo convalescent sera diluted 1:10 (green, n = 5) or 1:1 (blue, n = 5) prior to s.c. challenge with 102 FFU POWV-LB. Rag1−/− mice that received POWV-Spo sera diluted 1:10 (**p = 0.031) or 1:1 (**p = 0.013) had significantly prolonged survival times relative to Rag1−/− mice receiving saline (Mantel-Cox test). All data are reported as mean ± SEM.