Table 4.

Tabular presentation of the results of subgroups analysis

Subgroup		Effect size and 95% interval				Null hypothesis		Heterogeneity
		Number Studies	Proportion of patient deaths	Lower limit	Upper limit	Z-value	P value	Q-value	df	P value	I2
Predictive power of REMS	High	17	0.0872	0.0407	0.1771	-5.67	<0.001	10,881.68	16	<0.001	99.85
	Low	5	0.0859	0.0204	0.2973	-3.08	0.002	184.62	4	<0.001	97.83
Age	≤60	8	0.0857	0.0398	0.1749	-5.69	<0.001	308.67	7	<0.001	97.73
	>60	12	0.1044	0.0566	0.1847	-6.34	<0.001	1,856.35	11	<0.001	99.41