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. 2022 Jan 31;135(5):jcs258644. doi: 10.1242/jcs.258644

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — HDLs do not alleviate the stress response mediated by SERCA knockdown. (A) SERCA1, SERCA2 and SERCA3 expression in DLD-1 cells was assessed by western blotting. C2C12 and MCF-7 cell lysates were used as positive controls for SERCA1 and SERCA3, respectively. (B) Knockdown efficiency of SERCA2 in DLD-1 cells. (C) The mRNA expression of SERCA2 and ER stress markers (BIP, CHOP and XBP1s) in SERCA2-knockdown cells. (D) Effect of HDLs on the induction of ER stress marker mRNA expression induced by SERCA2 knockdown. In panels C and D, the results are normalized to the expression values obtained in untreated cells (dashed line). Symbols with a given shape and shading are derived from a given independent experiment. The black lines correspond to the mean. P-values were calculated with a two-tailed paired t-test; ns, not significant.