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. 2022 Feb 22;135(4):jcs259196. doi: 10.1242/jcs.259196

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Mutation of Adad2 results in altered transcript abundance and ribosome association of specific transcript classes. (A,B) Comparison of (A) total transcript abundance and (B) ribosome association in wild-type and Adad2^M/M Ribotag samples (green, downregulated in mutant; purple, upregulated in mutant) identifies many transcripts with differential ribosome association (DRA) in Adad2 mutant testes. (C) Significantly enriched ontological categories for DRA transcripts identifies cell cycle and DNA damage response (DDR) as significantly enriched in transcripts with increased ribosome association in the mutant. (D) Total abundance and ribosome association (derived from RNA-sequencing) relative to wild type of select cell cycle and DDR-related genes identified as DRA confirms increased ribosome association and minimal abundance changes in mutant testes. Dashed line represents wild-type mean. Arrow indicates the gene of interest, Mdc1. Data are mean±s.d.