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. 2022 Feb 28;10:832808. doi: 10.3389/fbioe.2022.832808

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Copyright © 2022 Yao, Yang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Hematological analysis of the PTH-i expression of the bone-defected rats was treated with electroacupuncture for 4, 8, and 12 weeks. (B) The osteoclast activation protein (p38) and osteoblast differentiation/mineralization proteins (ALP, OPN, and OCN) in the bone-defected tissues after treating with electroacupuncture stimulation were analyzed by using the Western blot assay. The control group indicated the rats with the implanted GGT scaffold and without ES treatment. (The number of rats per group = 4, *p < 0.05.)