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. 2022 Feb 14;13(3):443–448. doi: 10.1021/acsmedchemlett.1c00604

Scheme 1. Synthesis of Hybrid Compounds 4ad and 6ad and (inset) Crystal Structure of 4c.

Scheme 1

Reagents and conditions: (i) Al(OiPr)3, cyclohexanone, toluene, reflux, 12 h; (ii) 3ad, p-TsOH, EtOH, MW, 100 °C, 15 min; (iii) PCC, CH2Cl2, rt, 24 h.