Table 1.
Demographic and clinical information of hospitalized patients referred for inter-hospital transfer to the Johns Hopkins Hospital adult inpatient liver unit, stratified by time period starting in the third quarter (Q3) of 2019
| Overall (n = 459) | 2019 Q3 (n = 55) | 2019 Q4 (n = 70) | 2020 Q1 (n = 78) | 2020 Q2 (n = 65) | 2020 Q3 (n = 98) | 2020 Q4 (n = 93) | P value | |
|---|---|---|---|---|---|---|---|---|
| Age, median (P25–P75), y | 53 (39–62) | 54 (44–61) | 54 (37–59) | 54 (40–65) | 51 (38–60) | 51.5 (39–62) | 50 (40–64) | 0.68 |
| Men, no. (%) | 264 (57.5) | 27 (49.1) | 36 (51.4) | 49 (62.8) | 41 (63.1) | 60 (61.2) | 51 (54.8) | 0.36 |
| State, no. (%) | 0.39 | |||||||
| Maryland | 323 (70.4) | 39 (70.9) | 50 (71.4) | 53 (68.0) | 47 (72.3) | 70 (71.4) | 64 (68.8) | |
| Virginia | 76 (16.6) | 9 (16.4) | 9 (12.9) | 14 (18.0) | 12 (18.5) | 13 (13.3) | 19 (20.4) | |
| Pennsylvania | 23 (5.0) | 0 (0) | 8 (11.4) | 7 (9.0) | 4 (6.2) | 1 (1.0) | 3 (3.2) | |
| West Virginia | 19 (4.1) | 4 (7.3) | 2 (2.9) | 2 (2.6) | 0 (0) | 7 (7.1) | 4 (4.3) | |
| Delaware | 10 (2.2) | 1 (1.8) | 0 (0) | 1 (1.3) | 1 (1.5) | 4 (4.1) | 3 (3.2) | |
| District of Columbia | 8 (1.7) | 2 (3.6) | 1 (1.4) | 1 (1.3) | 1 (1.5) | 3 (3.1) | 0 (0) | |
| Liver disease*, no. (%) | ||||||||
| ALD-RD†† | 191 (41.6) | 18 (37.7) | 22 (31.4) | 31 (39.7) | 27 (41.5) | 50 (51.0) | 43 (46.2) | 0.007 |
| Other ALD** | 69 (15.0) | 10 (18.2) | 11 (15.7) | 12 (15.4) | 9 (13.9) | 15 (15.3) | 12 (12.9) | 0.47 |
| NASH | 55 (12.0) | 6 (10.9) | 5 (7.1) | 8 (10.3) | 7 (10.8) | 14 (14.3) | 15 (16.1) | 0.09 |
| DILI | 33 (7.2) | 3 (5.5) | 6 (8.6) | 4 (5.1) | 1 (1.5) | 7 (7.1) | 12 (12.9) | 0.17 |
| HCV | 27 (5.9) | 5 (9.1) | 1 (1.4) | 7 (9.0) | 3 (4.6) | 6 (6.1) | 5 (5.4) | 0.82 |
| Other | 70 (15.3) | 9 (16.4) | 13 (18.6) | 12 (15.4) | 17 (26.2) | 10 (10.2) | 9 (9.7) | 0.10 |
| Undiagnosed*** | 43 (9.4) | 8 (14.6) | 13 (18.6) | 8 (10.3) | 6 (9.2) | 4 (4.1) | 4 (4.3) | <0.001 |
| COVID-19, no. (%) | 7 (1.5) | NA | NA | 0 (0) | 1 (1.5) | 2 (2.0) | 4 (4.3) | 0.39† |
*A patient may have multiple liver diagnoses.
**ALD with no reported alcohol use during the preceding 6 months.
***Liver disease etiology not yet diagnosed at the time of referral.
†Based on 2020 Q2 through Q4 since 2020 Q1 only minimally overlapped the COVID-19 pandemic.
††Recent drinking (RD) is defined as alcohol use within the previous 6 months.