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. 2022 Mar 11;10(3):e004044. doi: 10.1136/jitc-2021-004044

Figure 3.

Figure 3

Neoadjuvant in situ eCPMV immunotherapy induced a high neutrophilic infiltration in tumor samples and tumor emboli. Representative histopathology and immunostaining of tumor tissues from pretreatment/control and post-treatment samples. A strong neutrophilic infiltration is seen in post-treatment tumor tissues and emboli than in pretreatment tissues and tumor emboli as indicated by H&E and myeloperoxidase (MPO) expression. Higher Ki-67 proliferation index is observed in pretreatment tumor tissues and emboli than in post-treatment tumor tissues and emboli. There is no difference in cleaved caspase 3 (CC-3) immunolabeling between pretreatment tumor tissues and emboli than in post-treatment tumor tissues and emboli. eCPMV, empty cowpea mosaic virus.