| Methods |
Method of randomisation: not mentioned
Blinding: not mentioned, but placebo was used
Analysis: intention‐to‐treat analysis
Post‐randomisation exclusions: none
Definition of outcome: stated |
| Participants |
Location: Oska University Medical School, Japan
Rx: 13 (female % not mentioned)
Controls: 11 (female % not mentioned)
Age range: Mean age 54.2 years
Entry criteria: admission within 24 hours between November 1986 and December 1989, Hunt and Hess score 1 to 4, aneurysm verified on angiography
Exclusion criteria: severe cardiac, hepatic or renal insufficiency
Type/timing of aneurysm treatment: surgical clipping within 48 hours after onset SAH
Comparability of treatment groups: good with regard to prognostic factors |
| Interventions |
Rx: Cataclot 1ug/kg/min via continuous infusion, starting after surgery continued for 8 to 14 days
Controls: placebo in same dose/route |
| Outcomes |
(1)Symptomatic vasospasm
(2) Functional outcome |
| Notes |
Follow up: 1 month
Adverse effects: none |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
