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. 2022 Mar 11;10(3):e003533. doi: 10.1136/jitc-2021-003533

Figure 4.

Figure 4

Expression of dendritic cell maturation, activation, and licensing genes in the vaccine-site microenvironment according to treatment group and injection strategy. (A) Comparisons demonstrating that pICLC increases the expression of dendritic cell maturation, activation, and licensing genes early after injection but does not significantly increase their expression compared with week 1 after repeated same-site injection. (B) Comparisons demonstrating that expression of dendritic cell maturation, activation, and licensing genes is lower after rotating vaccine injections compared with same-site injections. Boxplots denote the median and IQR, and boxes are colored according to vaccine formulation. Expression is shown as log normalized counts. Total n=90 samples. All p-values were FDR-corrected. *FDR-p <0.05, **FDR-p <0.01, ***FDR-p <0.001, ****FDR-p <0.0001. FDR, false discovery rate; IFA, incomplete Freund’s adjuvant; ns, not significant; P, peptide; pICLC, polyICLC; RV, rotating-site vaccination; SSV, same-site vaccination; W1, week 1; W3, week 3.