| Stage 1 | Stage 2 | Stage 3 | Stage 4 | Stage 5 | |
|---|---|---|---|---|---|
| Cumulative sample size per treatment arm reaching the respective stage | 91 | 182 | 344 | 477 | 724 |
| New samples per continued treatment arm and per stage | 91 | 91 | 162 | 133 | 247 |
| Overall cumulative sample size if no arm is dropped in any stage | 273 | 546 | 1032 | 1431 | 2172 |
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