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Comparison of experimental design of T2 and T3 studies.
| Pilot experiment (T2) | Complete experiment (T3) | |
|---|---|---|
| Window of exposure | In utero & lactation | In utero |
| Treatments | DMSO, 50 nM TBT | DMSO, 5 nM TBT, 50 nM TBT |
| Generation analyzed | F4 | F3 |
| HFD start age (weeks) | 19 | 12 |
| HFD end age (weeks) | 25 | 20 |
| Euthanasia age (weeks) | 33 | 28 |
| Fasting length | 4 h | Overnight (~16 h) |
