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. 2022 Mar 14;23(1):36. doi: 10.1186/s10194-022-01405-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — No statistically significant difference was found between hesperidin and DMSO groups regarding the a) duration of grooming (p = 0.6) b) the number of head shakes (p = 0.82). c) duration of freezing (p = 0.22) and d) duration of immobility (p = 0.146). e) Grooming duration, f) number of head shakes g) duration of freezing, and h) duration of immobility were higher in the chronic mefenamic acid group compared to its vehicle (p = 0.001, p = 0.01, p = 0.018 and p = 0.01 respectively). i) Grooming duration and j) number of head shakes were similar between the chronic mefenamic acid plus hesperidin and chronic mefenamic acid plus DMSO groups (p = 0.113, p = 0.17, respectively) while k) duration of freezing (p = 0.048) and l) duration of immobility (p = 0.03) were higher in chronic mefenamic acid plus hesperidin group. *p < 0.05 vs. controls