Table 4.

KEGG pathways and associated acetylated proteins found to be decreased in AH.

KEGG Pathway Enrichment	Uniprot Accession Gene ID for Decreased Acetylated Proteins
Metabolic pathways	AASS, ABAT, ACAA2, ACADVL, ACAT1, ACO2, ACOT1, ACOX1, ACSM2A, ACSS3, ADH1A, ADH1B, AGMAT, AHCY, AKR1C3, ALDH1A1, ALDH2, ALDH4A1, ALDH5A1, ALDH6A1, ALDH7A1, ALDH9A1, ALDOB, AOX1, ASL, ATP5A1, ATP5F1, ATP5H, ATP5O, BAAT, CBR1, CMPK1, COX4I1, COX5B, CPS1, DCXR, DLD, DLST, ECHS1, EHHADH, ENO1, FAHD1, FASN, FH, GAPDH, GLUD1, GOT2, GPI, GRHPR, HADH, HADHA, HADHB, HAO1, HIBCH, HMGCL, HMGCS2, HSD17B4, IDH1, IDH2, IVD, LDHA, MDH1, MDH2, MUT, NADK2, NNT, OTC, PCCB, PCK2, PNPO, PRDX6, PYGL, SCP2, SDHA, SHMT1, SHMT2, SUCLG1, TALDO1, TST, UGP2
Biosynthesis of antibiotics	AASS, ACAA2, ACAT1, ACO2, ALDH2, ALDH7A1, ALDH9A1, ALDOB, ASL, CAT, DLD, DLST, ECHS1, EHHADH, ENO1, FH, GAPDH, GOT2, GPI, HADH, HADHA, HADHB, HAO1, HMGCS2, IDH1, IDH2, LDHA, MDH1, MDH2, OTC, PCCB, PCK2, SDHA, SHMT1, SHMT2, SUCLG1, TALDO1, UGP2
Carbon metabolism	ACAT1, ACO2, ALDH6A1, ALDOB, CAT, CPS1, DLD, DLST, ECHS1, EHHADH, ENO1, FH, GAPDH, GLUD1, GOT2, GPI, HADHA, HAO1, HIBCH, IDH1, IDH2, MDH1, MDH2, MUT, PCCB, SDHA, SHMT1, SHMT2, SUCLG1, TALDO1
Valine, leucine and isoleucine degradation	ABAT, ACAA2, ACAT1, ALDH2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBCH, HMGCL, HMGCS2, IVD, MUT, PCCB
Peroxisome	ACOX1, BAAT, CAT, CRAT, ECH1, EHHADH, GSTK1, HAO1, HMGCL, HSD17B4, IDH1, IDH2, PRDX1, SCP2, SOD1, SOD2
Fatty acid degradation	ACAA2, ACADVL, ACAT1, ACOX1, ADH1A, ADH1B, ALDH2, ALDH7A1, ALDH9A1, ECHS1, ECI1, EHHADH, HADH, HADHA, HADHAB
Biosynthesis of amino acids	ACO2, ALDOB, ASL, CPS1, ENO1, GAPDH, GOT2, IDH1, IDH2, OTC, SHMT1, SHMT2, TALDO1
Glyoxylate and dicarboxylate metabolism	ACAT1, ACO2, CAT, DLD, GRHPR, HAO1, MDH1, MDH2, MUT, PCCB, SHMT1, SHMT2
Propanoate metabolism	ABAT, ACAT1, ACSS3, ALDH6A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, MUT, PCCB, SUCLG1
Glycolysis / Gluconeogenesis	ADH1A, ADH2B, ALDH2, ALDH7A1, ALDH9A1, ALDOB, DLD, ENO1, GAPDH, GPI, LDHA, PCK2
Huntington’s disease	APT5A1, ATP5F1, ATP5H, ATP5J, ATP5O, COX4I1, COX5B, SDHA, SLC25A5, SOD1, SOD2, TGM2
Citrate cycle (TCA cycle)	ACO2, DLD, DLST, FH, IDH1, IDH2, MDH1, MDH2, PCK2, SDHA, SUCLG1
Pyruvate metabolism	ACAT1, ALDH2, ALDH7A1, ALDH9A1, DLD, FH, GRHPR, LDHA, MDH1, MDH2, PCK2
Butanoate metabolism	ABAT, ACAT1, ACSM2A, ALDH5A1, ECHS1, EHHADH, HADH, HADHA, HMGCL, HMGCS2
Tryptophan metabolism	ACAT1, ALDH2, ALDH7A1, ALDH9A1, AOX1, CAT, ECHS1, EHHADH, HADH, HADHA
Fatty acid metabolism	ACAA2, ACADVL, ACAT1, ACOX1, ECHS1, EHHADH, FASN, HADH, HADHA, HADHB
Lysine degradation	AASS, ACAT1, ALDH7A1, ALDH9A1, ALDK2, DLST, ECHS1, EHHADH, HADH, HADHA
Parkinson’s disease	APT5O, ATP5A1, ATP5F1, ATP5H, ATP5J, COX4I1, COX5B, PARK7, SDHA, SLC25A5