Table 6.
Equivalence tests (TOST procedure) of the estimated effect sizes in Table 4 .
| EE | Heart Rate | Cardiac Output | Stroke Volume | Systemic Vascular Resistance | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| LB=-0.1 | UB=0.1 | LB=-5 | UB =5 | LB= -1 | UB=1 | LB=-10 | UB=10 | LB= -500 | UB=500 | |
| Dose [LT3] | 0.004 | 0.003 | 0.000 | 0.004 | 0.002 | 0.011 | 0.038 | 0.018 | 0.023 | 0.002 |
| Dose [LT4] | 0.004 | 0.002 | 0.000 | 0.005 | 0.003 | 0.005 | 0.074 | 0.008 | 0.009 | 0.004 |
| Time | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| Time2 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| Dose [LT3] * Time | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| Dose [LT4] * Time | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| Dose [LT3] * Time2 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| Dose [LT4] * Time2 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
LB, lower bound; UB, upper bound. Two one-sided t-tests were conducted for each estimated fixed effects of the models presented in Table 4 . P-values presented in this table indicate the significance of the TOST procedure, p-values < 0.05 indicate that null hypothesis that a fixed effect does not fall in the region of [LB, UB] are rejected, and we thus accept the alternative hypothesis that the fixed effect is zero.