Table 5:
Pharmacokinetics nab-paclitaxel
| Dose Level (mg/m2) |
Study Day | N | Cmax (mg/L)* | AUC 0-t (mg/L x hr) | |||
|---|---|---|---|---|---|---|---|
| Plasma | Peritoneal | Plasma | Peritoneal | Ratio | |||
| 35 | Cycle 1, Day 1 | 1 | 0.06 | 25.1 | 0.6 | 89.3 | 148 |
| 35 | Cycle 1, Day 15 | 1 | 0.06 | 31.1 | 0.5 | 93.2 | 186 |
| 70 | Cycle 1, Day 1 | 1 | 0.1 | 24.9 | 1.5 | 299.2 | 199 |
| 70 | Cycle 1, Day 15 | 1 | 0.1 | 30.3 | 1.6 | 321.4 | 201 |
| 90 | Cycle 1, Day 1 | 2 | 0.2 (0.1–0.2) | 39.8 | 1.6 (1.1–2.2) | 206.8 | 94 |
| 90 | Cycle 1, Day 15 | 2 | 0.2 (0.1–0.2) | 46.1 (33.9–58.4) | 1.9 (1.1–2.7) | 193.9 | 72 |
| 112.5 | Cycle 1, Day 1 | 4 | 0.3 (0.04–0.4) | 65.8 (29.3–1473.1) | 3.0 (0.8–4.2) | 304.9 (210.5–427.2) | 134 (50–389) |
| 112.5 | Cycle 1, Day 15 | 4 | 0.2 (0.03—0.3) | 34.5 (28.0–79.4) | 2.5 (0.6–3.7) | 289.6 (229.9–358.0) | 118 (88–403) |
| 140 | Cycle 1, Day 1 | 5 | 0.5 (0.2–0.5) | 65.8 | 4.3 (3.6–6.3) | 339.6 | 116 |
| 140 | Cycle 1, Day 15 | 5 | 0.5 (0.3–1.0) | 73.6 (53.2–97.0) | 4.5 (2.8–11.8) | 251.5 (244.0–259.1) | 239 (87–392) |
| 170 | Cycle 1, Day 1 | 3 | 0.4 (0.3–0.5) | 243.3 | 6.0 (4.8–7.2) | 622.7 | 260 |
| 170 | Cycle 1, Day 15 | 3 | 0.7 (0.4–1.0) | 146.8 | 3.2 | 978.0 | 306 |
*
Median (range)