Table 4.

Results of secondary endpoints

	Treatment Group	Treatment or Control	Time Point	Median	Percent Change ([Baseline – 6 month]/Baseline)
POSAS- Patient Rating	Group 1	Treatment	Baseline	36.0	↓66.7
			6 month	12.0
		Control	Baseline	37.0	↓71.6
			6 month	10.5
	Group 2	Treatment	Baseline	32.0	↓28.1
			6 month	23.0
		Control	Baseline	30.5	↓41.0
			6 month	18.0
	Group 3	Treatment	Baseline	26.5	↓50.9
			6 month	13.0
		Control	Baseline	28.5	↓40.4
			6 month	17.0
POSAS- Observer Rating	Group 1	Treatment	Baseline	16.5	↓45.5
			6 month	9.0
		Control	Baseline	16.5	↓24.2
			6 month	12.5
	Group 2	Treatment	Baseline	19.0	↓57.9
			6 month	8.0
		Control	Baseline	14.0	0
			6 month	14.0
	Group 3	Treatment	Baseline	18.0	↓27.8
			6 month	13.0
		Control	Baseline	16.5	↓27.3
			6 month	12.0
Collagen	Group 1	Treatment	Baseline	48.7	↑17.0
			6 month	57.0
		Control	Baseline	52.0	↑8.7
			6 month	56.5
	Group 2	Treatment	Baseline	51.0	↑17.6
			6 month	60.0
		Control	Baseline	50.5	↑20.8
			6 month	61.0
	Group 3	Treatment	Baseline	47.7	↑18.9
			6 month	56.7
		Control	Baseline	52.5	↑13.0
			6 month	59.3
Moisture (%)	Group 1	Treatment	Baseline	63.0	↓0.8
			6 month	62.5
		Control	Baseline	65.3	↓6.3
			6 month	61.2
	Group 2	Treatment	Baseline	60.7	↑4.9
			6 month	63.7
		Control	Baseline	62.7	↑0.5
			6 month	63.0
	Group 3	Treatment	Baseline	63.2	↓1.9
			6 month	62.0
		Control	Baseline	66.2	↓3.3
			6 month	64.0