Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Comparison of kinetic parameters of CYP3A4 activity among COS-1 cell homogenates prepared by the Bac-Mam system, HLM, and Supersomes™.
| Vmax (pmol/min/mg protein) | Km (μM) | |
|---|---|---|
| COS-1 homogenates | 1.0 ± 0.1 | 1.5 ± 0.4 |
| HLM | 31.0 ± 1.6 | 4.3 ± 0.6 |
| Supersomes™ | 37.2 ± 2.8 | 1.1 ± 0.3 |
Data were fitted to the Michaelis-Menten equation (Figures 3A,B). Each parameter is shown as the calculated value ±S.E.M. HLM, human liver microsomes.
