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. 2022 Feb 28;13:812996. doi: 10.3389/fimmu.2022.812996

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Copyright © 2022 Wang, Yang, Shang, Liang, Wang, Feng, Yu, Li, Gao, Li and Luo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation of differential metabolites and clinical features. (A) Integrative network of associations reflecting the interactions of differential metabolites (PsA vs HC) and lymphocyte subpopulation via Cytoscape (3.8.2). Network revealed both significant (p <0.01) and suggestive associations (0.01< p <0.05) between differentially abundant metabolites and lymphocyte subpopulation in PsA. Yellow oval nodes represent immune cells, red and blue diamond nodes represent the increase and decrease of metabolites in PsA, respectively. Lines connecting nodes indicate positive (red) or negative (blue) correlations. The full lines and dotted lines indicate significant correlation and suggestive correlation respectively. (B) Correlation of differential metabolites (PsA vs HC) and cytokines in PsA; (C) Correlation of differential metabolites (PsA vs RA) and Cytokines in PsA.