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. 2022 Mar 7;17(1):441–452. doi: 10.1515/med-2022-0441

Figure 3.

Figure 3

miR-195 inhibited cell proliferation, cell migration, and invasion in osteosarcoma. (a) The proliferation activity of osteosarcoma cells was detected by MTT assay. Left: the proliferation ability of U2-OS cells was significantly decreased in the group miR-195/up (n = 6; day 4: *p < 0.001) and significantly increased in the group miR-195/down in vitro (n = 6; day 4: #p < 0.001). Right: the proliferation ability of 143B cell was significantly decreased in the group miR-195/up (n = 6; day 4: *p < 0.001) and significantly increased in the group miR-195/down in vitro (n = 6; day 4: #p < 0.001). The error bar represents the standard variation of the OD490 in the U2-OS or 143B cells transfected with lentiviruses overexpressing or inhibiting miR-195. (b) The migration ability of osteosarcoma cells at 24 h using wound healing assay was significantly decreased in the group miR-195/up (n = 6, ×200). (c) The invasion ability of osteosarcoma cells at 24 h using Transwell invasion assay was significantly decreased in the miR-195/up group and significantly increased in the miR-195/down group (n = 6, ×200).