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. 2022 Mar 7;17(1):441–452. doi: 10.1515/med-2022-0441

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© 2022 Tianhao Sun et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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The methylation of miR-195 was one of the reasons why miR-195 decreased. (a) The prediction results showed that the promoter region of miR-195 is full of CPG islands. (b) Bisulfite sequencing PCR (BSP) assay showed that the methylation levels of the miR-195 promoter region were significantly downregulated on cells treated with 5-aza-2′-dc (n = 6). (c) The expression level of miR-195 was significantly upregulated in U2-OS and 143B cells treated with the demethylation reagent in vitro (n = 6). The error bar represents the standard variation of the miR-195 levels in the U2-OS or 143B cells treated with 5-aza.