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. 2022 Mar 7;17(1):441–452. doi: 10.1515/med-2022-0441

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© 2022 Tianhao Sun et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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Methylation might promote osteosarcoma cell proliferation, migration, and invasion. (a) The proliferation activity of osteosarcoma cells was detected by MTT assay. MTT assay showed that the proliferation was significantly decreased in U2-OS and 143B cells treated with 5-aza-2′-dc (n = 6, day 4: p < 0.001). The error bar represents the standard variation of the OD490 in the U2-OS or 143B cells treated with 5-aza. (b) The migration ability of osteosarcoma cells at 24 h was significantly decreased in the cells treated with 5-aza-2′-dc (n = 6, ×200). (c) The invasion ability of osteosarcoma cells at 24 h was significantly decreased in the cells treated with 5-aza-2′-dc (n = 6, ×200).