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. Author manuscript; available in PMC: 2022 Mar 14.
Published in final edited form as: Hepatology. 2020 Mar 25;72(2):486–502. doi: 10.1002/hep.31059

FIG. 7.

FIG. 7.

Maturation of lipophagic organelles in hepatocytes is dependent upon a Rab10-Dyn2 complex. A model depicting direct interaction of the Rab10 and Dyn2 GTPases by effector and middle domains, respectively. Rab10 may coordinate the recruitment of Dyn2 dimers to LD-associated membranes, leading to Dyn2 contractile polymer assembly and eventual tubulation/scission of these membrane targets. The coordinated efforts of Rab10 and Dyn2 are required for functional maturation of these lipophagic compartments in regulating hepatic lipid stores. Abbreviations: GED, GTPase effector domain; MID, middle; PH, pleckstrin homology; PM, plasma membrane; PRD, proline-rich domain.