TABLE 4.

In vitro activities of TBG-MINO and comparative antibiotics against anaerobic bacteria

Organism (no. of isolates)	Antibiotic	MIC (μg/ml)
		Range	50%	90%
Bacteroides fragilis group (12)	TBG-MINO	0.25–2	0.5	2
	DMG-MINO	0.25–0.5	0.25	0.5
	DMG-DMDOT	0.25–0.5	0.25	0.5
	Minocycline	0.06–4	2	4
	Cefoxitin	2–>32	16	>32
	Imipenem	≤0.06–2	0.12	2
Bacteroides fragilis (14)	TBG-MINO	0.5–8	2	2
	DMG-MINO	0.25–2	1	1
	DMG-DMDOT	0.5–2	1	2
	Minocycline	≤0.06–8	8	8
	Cefoxitin	1–8	8	8
	Imipenem	≤0.06–0.25	≤0.06	0.12
Prevotella spp. (11)	TBG-MINO	0.12–1	0.5	1
	DMG-MINO	≤0.06–0.5	0.25	0.5
	DMG-DMDOT	≤0.06–2	0.5	2
	Minocycline	≤0.06–16	8	16
	Cefoxitin	0.25–4	1	2
	Imipenem	≤0.06	≤0.06	≤0.06
Clostridium difficile (10)	TBG-MINO	≤0.06–0.25	0.12	0.12
	DMG-MINO	≤0.06–0.12	0.12	0.12
	DMG-DMDOT	≤0.06–0.12	0.12	0.12
	Minocycline	≤0.06–4	0.03	4
	Cefoxitin	>32	>32	>32
	Imipenem	2–16	4	4
Clostridium perfringens (10)	TBG-MINO	0.12–4	0.5	1
	DMG-MINO	0.12–4	0.25	2
	DMG-DMDOT	0.12–4	0.25	2
	Minocycline	≤0.06–8	≤0.06	4
	Cefoxitin	0.25–1	0.5	1
	Imipenem	≤0.06	≤0.06	≤0.06
Anaerobic gram-positive cocci (15)	TBG-MINO	≤0.06–0.25	0.12	0.25
	DMG-MINO	≤0.06–0.12	≤0.06	0.12
	DMG-DMDOT	≤0.06–0.5	0.12	0.5
	Minocycline	0.12–16	4	16
	Cefoxitin	≤0.06–16	0.12	16
	Imipenem	≤0.06–1	≤0.06	1