Figure 4.

As opposed to dobutamine (Dob), TA1 preserves high-energy phosphates during high workload.

Phosphocreatine (PCr; A) and PCr/ATP (B) progressively declined with increasing Dob concentrations and remained grossly unaffected by TA1. Calculated cytosolic free (ADP; C) and inorganic phosphate (Pi; D) progressively increased with Dob increments and were preserved by TA1. n=15 (TA1) and 11 (Dob). Data shown are mean±SEM. Averages of the 2 time point measurements per substance concentration were compared. P values were obtained by paired t tests (baseline vs incremental concentrations of Dob or TA1) and unpaired t tests (60 nmol/L TA1 vs 120 nmol/L Dob). *P<0.05 vs TA1-zero baseline. ††P<0.01, †††P<0.001, and ††††P=0.0001 vs Dob-zero baseline, respectively. ‡P<0.05 vs 120 nmol/L Dob. N for all time points is provided in Table S3.