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. 2022 Feb 28;12:851784. doi: 10.3389/fcimb.2022.851784

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Copyright © 2022 Thöming and Häussler

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cross-tolerance of biofilm-grown cells. The dependence between the log2-transformed BTF-4 of the three antibiotics on all clinical isolates is depicted. The correlation coefficient between the BTF-4 of tobramycin (TOB) and ciprofloxacin (CIP) was 0.4148 (A). No correlation was observed between the BTF-4 of colistin (COL) and TOB (B) or CIP (C). BTF-4 - minimum antibiotic concentration killing 99.99 % of the biofilm-grown cells (MCK99.99; 4-log reduction) divided by the minimal inhibitory concentration (MIC) of the individual isolate. Dots represent the log2-transformed BTF-4 of the individual clinical isolates. Darker shades indicate overlapping datapoints.