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. Author manuscript; available in PMC: 2022 Mar 18.
Published in final edited form as: Eur Respir J. 2021 Mar 18;57(3):2004077. doi: 10.1183/13993003.04077-2020

FIGURE 1.

FIGURE 1

Functionality of selected first-generation nucleic acid amplification tests (NAATs) for Mycobacterium tuberculosis complex (MTBC) diagnostics compared with targeted next-generation sequencing (NGS) and whole genome sequencing (WGS). All currently World Health Organization-endorsed NAATs are listed and underlined [10]. Additional assays are included but many more exist. Unless otherwise marked (#), the assays are only capable of identifying MTBC rather than differentiating nontuberculous mycobacteria. Cluster analysis is not currently a feature of Spit Seq but could be integrated and the resolution of Deeplex is considerably lower than WGS in this context. AMK: amikacin; AST: antimicrobial susceptibility testing; BDQ: bedaquiline; CAP: capreomycin; CFZ: clofazimine; EMB: ethambutol; ETH: ethionamide; FQs: fluoroquinolones; INH: isoniazid; KAN: kanamycin; LZD: linezolid; PZA: pyrazinamide; RIF: rifampicin; RUO: research use only; STR: streptomycin.