Table 2.
Comparison of characteristics between those within and outside 95% of normal distribution curves in the study population
| Variables | Cmax (mg/L) | Elimination rate (per day) | ||||
|---|---|---|---|---|---|---|
| Within 95% of ND (n= 201) | Outside 95% of ND (n= 19) | P-values | Within 95% of ND (n=206) | Outside 95% of ND (n=14) | P-values | |
| Age (years) $ | 67.1 (13.3) | 61.7 (13.7) | 0.7 | 68.6 (12.7) | 64.2 (14.5) | 0.6 |
| Body weight (kg) $ | 75 (18.4) | 77.6 (14.1) | 0.4 | 72.8(19) | 81.6(12) | 0.2 |
| TTR (%) $ | 65.6 (17.2) | 64.7 (16.4) | 0.6 | 65.7 (16.1) | 65(21) | 1 |
| WSI $ | 0.7 (0.4) | 0.3 (0.1) | 0.0001* | 0.8 (0.4) | 0.3 (0.1) | 0.0001* |
| Log INR variability $ | -0.8 (0.2) | -0.9 (0.2) | 0.06 | -0.8 (0.2) | -0.9 (0.2) | 0.06 |
| WCM $ | -1.2 (1.2) | -1.8 (0.9) | 0.004* | -1.1 (1.2) | -1.7 (1.1) | 0.08 |
| Potentially interacting drugs [n (%)] | 123 (61.2) | 12 (63.2) | 0.9 | 135 (65.5) | 8 (57.1) | 0.5 |
Y-Young; M-Middle-aged & older adults; E – Elderly; VE – Very elderly; TTR – Time spent in therapeutic range; WSI – warfarin sensitive index; WCM – Warfarin composite measure; ND – Normal distribution
$ - Represented in mean (SD)
* - Statistically significant.