Table 9.
The estimated in vivo properties of CQ and HCQ enantiomers obtained from the data when the protein binding was obtained with the 15 % IPA isocratic conditions.
| Property | (+)- S CQ | (-)- R CQ | (+)- S HCQ | (-)-R HCQ |
|---|---|---|---|---|
| % bound HSA | 79.9 | 79.9 | 79.9 | 79.9 |
| % bound AGP | 82.0 | 81.0 | 85.1 | 87.3 |
| calc% PPB | 89.9 | 89.7 | 89.0 | 88.9 |
| CHI logD2 | -1.2 | -1.2 | -1.3 | -1.3 |
| CHI logD7.4 | 0.8 | 0.8 | 0.7 | 0.7 |
| CHI logD10.5 | 2.7 | 2.7 | 2.1 | 2.1 |
| CHIlogP | 2.68 | 2.7 | 2.1 | 2.1 |
| CHI IAM | 46.92 | 46.9 | 45.4 | 45.4 |
| CAD-likeness | 82.89 | 82.9 | 73.6 | 73.6 |
| %BTB | 97.26 | 97.3 | 96.7 | 96.7 |
| est log k BB | 0.96 | 1.0 | 0.9 | 0.9 |
| Brain to plasma | 4.06 | 4.0 | 3.1 | 3.0 |
| log Vd | 0.94 | 0.9 | 0.8 | 0.8 |
| Vd L/kg | 8.65 | 8.7 | 6.7 | 6.6 |
| log Vdu | 1.63 | 1.6 | 1.5 | 1.5 |
| V du | 43.01 | 43.0 | 33.5 | 33.3 |
| DEmax% | 2.33 | 2.3 | 23.0 | 3.0 |
| % lung tissue binding | 96.05 | 95.1 | 92.6 | 92.7 |