Table 3.

Summary of grade 3 or higher neurologic toxicities

		Early (<6 months post-chemoradiation)
Patient	MGMT* methylation status	Type	Grade	Interval from RT† (months)	Treatment
1	Negative	Seizure, worsened hemiparesis, imbalance	3	0.6	Steroids
2	Positive	Worsened gait, sensory neglect	3	3	Steroids, bevacizumab
3	Negative	Worsened hemiparesis and gait	3	3	Steroids, bevacizumab
4	Positive	Seizure, aphasia, worsened hemiparesis	4	During RT	Steroids, debulking surgery
Late (>6 months post-chemoradiation)
5	Negative	Seizures	3	10	Bevacizumab
6	Positive	Hemiparesis, worsened gait and word-finding difficulty	3	17	Bevacizumab

^*MGMT = O⁶-methylguanine-DNA methyltransferase;

^†RT=radiation therapy