Table 1.

Number and reporting rate of symptoms/clinical signs most frequently notified in spontaneous 4cMen B vaccine AEFI-reports. Puglia Region (Italy), 2014–2019

Symptom/clinical sign	n	Reporting rate (× 100.000 dosses)
Injection site reactions (redness, skin rash, swelling, local pain)	138	17.0
Fever, hyperpyrexia	94	12.9
Neurological symptoms	74	8.8
Hypotonic-hyporesponsive episode	11	1.4
Agitation, nervousness	20	2.5
Sleep disorders	12	1,5
Fatigue, weakness, headache	22	2.7
Seizure, clonus, dyskinesia	7	0.9
Excessive, inconsolable crying	13	1.6
Dizziness, lipothymia	3	0.4
Gastrointestinal diseases	31	3,8
Allergic reaction	6	0.9
Lymphadenitis	2	0.3
Other local signs/symptoms	50	7.7