Table 3.
Significant (FDR<0.05) associations between methylation of PM2.5-associated DMRs and mRNA expression of nearby genes
| Chr | Start | End | Illumina Transcript | Gene (hg19) | β (95% CI) | P-value | FDR Cut-Off |
|---|---|---|---|---|---|---|---|
| 7 | 27,183,274 | 27,184,109 | ILMN_1753613 | HOXA5 | −0.288 (−0.332, −0.243) | 1.5x10−34 | 2.8x10−3 |
| 7 | 27,183,274 | 27,184,109 | ILMN_1739582 | HOXA9 | 0.168 (0.118, 0.218) | 8.1x10−11 | 5.6x10−3 |
| 7 | 27,183,274 | 27,184,109 | ILMN_1689336 | HOXA10 | 0.079 (0.047, 0.112) | 2.1x10−6 | 8.3x10−3 |
| 16 | 11,374,865 | 11,374,865 | ILMN_1738866 | DEXI | 0.012 (0.004, 0.019) | 2.8x10−3 | 1.1x10−2 |
| 5 | 1,594,282 | 1,594,863 | ILMN_1800197 | MRPL36 | 0.014 (0.005, 0.024) | 3.7x10−3 | 1.4x10−2 |
DMR, differentially methylated region; FDR, false discovery rate; CI, confidence interval.