Table 4.

RICHS placenta expression levels (N = 230) of miRNA associated with GA at birth (P < 0.050) in MADRES^a.

miRNA	N (%) Detectable	Median Count	Count Range
let-7b-5p*	230 (100.0)	317	132–1,800
let-7d-5p	230 (100.0)	93	34–1095
miR-126-3p*	230 (100.0)	16,085	8,629–30,756
miR-142-3p	230 (100.0)	101	26–503
miR-150–5p	230 (100.0)	30	11–227
miR-15a-5p*	230 (100.0)	330	103–994
miR-15b-5p*	230 (100.0)	590	228–4505
miR-16-5p	230 (100.0)	4,016	2,187–18,293
miR-188-5p*	230 (100.0)	7	1–22
miR-199b-5p	230 (100.0)	693	326–1,279
miR-19b-3p*	230 (100.0)	251	56–940
miR-20a-5p	230 (100.0)	451	132–898
miR-20b-5p	230 (100.0)	21	8–121
miR-21-5p	230 (100.0)	74,655	39,337–165,849
miR-210-3p*	230 (100.0)	29	5–114
miR-212-3p*	122 (53.0)	1	0–18
miR-221-3p	230 (100.0)	3,499	1,770–5,658
miR-26b-5p	230 (100.0)	20,053	7,981–31,070
miR-29b-3p*	230 (100.0)	393	117–1,721
miR-320e	149 (64.8)	1	0–5
miR-331–3p	230 (100.0)	73	34–120
miR-374a-5p	230 (100.0)	971	281–4,855
miR-4454*	230 (100.0)	6	2–27
miR-548y	174 (75.7)	2	0–5
miR-551b-3p	230 (100.0)	42	8–161
miR-584-5p*	230 (100.0)	373	170–741
miR-656-3p	230 (100.0)	69	19–177
miR-937-3p	22.6	1	0–3

^aThe percentage of RICHS placenta samples that had detectable levels (normalized count per million>1) of the specified miRNA is shown with the median and range placental count. If a miRNA did not meet the quality control standards for RICHS, as described in the Supplement, it was excluded from the post hoc investigation. *miRNA was significantly associated with GA at birth in MADRES after multiple testing correction (P_FDR<0.050).

Abbreviations Used: FDR, false discovery rate; GA, gestational age; MADRES, Maternal and Developmental Risks from Environmental and Social Stressors Study; miRNA, microRNA; RICHS, Rhode Island Children’s Health Study