Table 5. Simulation durations.

System	Simulation 1	Simulation 2	Simulation 3	Total
Hxk2 apo	5 ns + 274.79 ns	5 ns + 335.99 ns	5 ns + 495.15 ns	15 ns + 1105.93 ns
Hxk2G238V apo	5 ns + 275.55 ns	5 ns + 254.45 ns	5 ns + 511.76 ns	15 ns + 1041.76 ns
Hxk2 holo	5 ns + 245.00 ns	5 ns + 245.00 ns	5 ns + 507.13 ns	15 ns + 997.13 ns
Hxk2G238V holo	5 ns + 245.00 ns	5 ns + 245.00 ns	5 ns + 495.00 ns	15 ns + 985.00 ns

In all cases, we removed the initial five ns before subsequent analysis. For the sake of clarity, we list this removed segment first, followed by the larger segment used for analysis.