Figure 9.

Oral administration of L. paracasei sh2020 improved gut microbiota homeostasis in the context of anti-PD-1 therapy. (a-b) The α-diversity differences between the groups were estimated by the observed species (a), and ACE (b) (n = 3–5). (c) 3D-PCoA analysis of fecal samples based on the Bray-Curtis dissimilarity metric. (d) Community heatmap analysis at the genus level among different treatment groups (n = 3–5). (e) Correlation networks of Lactobacillus and tumor-infiltrating immune cells. (f) Representative images of H&E staining of the colon tissues in each group. ns, no significant difference, *P < .05.